Guanidine Hydrochloride CAS 50-01-1 is white crystalline powder (medical grade) or white or light yellow lump (technical grade). Its solubility is 200g/100g water, 76g/100g methanol, 24g/100g ethanol. It is almost insoluble in acetone, benzene and ether.
Guanidine HCL is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine Hydrochloride is useful for denaturation and refolding of proteins as well as in the recovery of periplasmic proteins and isolation of RNA. At higher concentrations, this strong denaturant has been reported to solubilize denatured insoluble proteins such as inclusion bodies. When utilized at lower concentrations, Guanidine Hydrochloride is noted to be useful in prompting the refolding of denatured proteins. Guanidine Hydrochloride is also been reported to allow return of enzymatic activity in protocols using Guanidine Hydrochloride as a first step.
|Quality Index||Medicine Grade||Reagent Grade||Industrial Grade|
|Appearance||White crystal powder||White crystal powder||White crystal powder or lump|
|Ammonium Chloride %≤||0.001||0.002||0.3||0.8|
|Insoluble in Water %≤||0.01||0.1||0.5||0.6|
|Moisture Content %≤||0.5||0.5||0.5||0.6|
|Ash Content %≤||0.05||0.05||0.2||0.5|
|Melting Point ºC||184-186||184-186||182-186||180-184|
|Relative density d204||1.354||1.354||1.354||1.354|
|Solubility in Water||Clear and colorless||Clear and colorless||Clear and colorless||Clear and colorless|
It is used as the intermediate of medicine, pesticide, dye and other organic compounds.
It is an important raw material to produce folic acid and sulfa drugs, also used as the anti-static agent of synthetic fiber.
It is an important raw material to produce sulfadiazine, sulfamerazine, sulfonamides II methylpyrimidine and folic acid.
Tech grade : 25kg plastic woven bag lined with PE bag
Medical grade : 25kg per cardboard drum