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Isotretinoin
  • CAS No.:

    4759-48-2
  • Molecular Formula:

    C20H28O2
  • Quality Standard:

    USP26/28,EP5
  • Packing:

    1,2,5,10kg/Tin
  • Mininmum Order:

    200kg

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  • Product Details

Isotretinoin, also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treatsevere nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

Specification

Description:               Yellow crystalline powder

Assay:                       98.0-102.0%

Standard:                  USP26/28,EP5


Application

Vitamin A class drugs. It can rapidly and strongly inhibit the cell proliferation and differentiation process of skin glands cells. It has a high effect on severe nodular cystic acne. This product has a high gastrointestinal absorption, but invalid for topical administration. 

Isotretinoin is an effective drug against acne. It takes effect on four processes of acne procedures, preventing the formation of acne lesions: inhibiting sebaceous secretion; inhibit the growth of acne bacillus; inhibiting sebaceous hyperplasia; anti-inflammatory effect. Isotretinoin has no affinity to Vitamin A acid receptors. 


It may also reduce the volume of the sebaceous glands, reducing the skin's DHT, down-regulate the expression of skin androgen receptor. Other possible mechanism includes reducing the hair follicle keratosis, antibacterial, anti-inflammatory effects and so on. 


Packing

1,2,5,10kg/Tin


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