PVP/VA 64 (VP/VA 64, Copovidone) Product Introduction
CAS No.：25086-89-9
Chemical name: Poly (1-vinylpyrrolidone co vinyl acetate)
INCI Name: VP/VA COPOYMER
Monomer ratio: VP: VA=60:40
Pharmacopoeia generic name: Copovidone, included in the Chinese Pharmacopoeia USP、EP、JP）
* PVP/VA Copolymer (Copovidone) Mainstream Model Description
* PVP/VA 73 powder /VA 73W 50% water solution/ VA 73 50% ethanol solution
Basic physical and chemical properties
Standard specifications and models
VP/VA 64 Powder: White free flowing hygroscopic powder (pharmaceutical grade main model)VP/VA 64W: 50% aqueous solution
VP/VA 64E: 50% ethanol solution
Solubility characteristics: soluble in water, methanol, ethanol, isopropanol; Insoluble in alkanes, ether, and mineral oil; Non-ionic polymer
K value (1% ethanol solution): 25~35Compared to pure PVP: lower moisture absorption and better film-forming flexibility; Compared to VA73, it has stronger hydrophobicity and better film-forming and moisture resistance; Balancing hydrophilicity and hydrophobicity, it has the strongest universality.
Core advantages
- Pharmacopoeia certified pharmaceutical excipients, the only VP/VA grade that can be used for pharmaceuticals
- The film is transparent, flexible, and has strong adhesion, making it less prone to brittle cracking
- Combining adhesive properties, suitable for wet granulation and direct tablet pressing
- Suitable for hot melt extrusion process, commonly used as a carrier for insoluble drug solid dispersions
- Good compatibility with the vast majority of anionic and cationic excipients, as well as daily chemical raw materials.
Main applications
1) Pharmaceutical field (core use)
Dry/wet adhesive for tablets, reducing brittleness and improving tablet hardness; Suitable for water sensitive drugsFilm coating film-forming agent, plasticizer additive
Solid dispersion carrier, improving the solubility of insoluble drugs
Micro pill coating, taste masking excipients, transdermal preparation matrix
2) Cosmetics field
Hair gel, styling spray, mousse styling film former; Moderate film formation, balancing formability and ease of rinsing.
3) Industrial sector
Water based adhesives, coatings, ink film-forming resins.
Distinguishing points: VP/VA64=Covidone (pharmaceutical compliant); VP/VA73/55/37 is only for daily chemical grade and does not have pharmacopoeia standards, so it cannot be used for pharmaceutical preparations.
Packaging and Storage
Packaging: 25kg cardboard drum lined with PE bag; Liquid specification 200kg plastic drum
Storage: Store in a cool, dry, and ventilated warehouse, with sealed containers to prevent moisture absorption and keep away from strong oxidants.Item |
VP/VA |
K value |
Vinylpyrrolidone |
Moisture |
Content |
PH value (5% aqueous.) |
|
VA73E |
70/30 |
30-38 |
<0.2% |
<0.5% |
50±2% |
- |
|
VA73W |
70/30 |
24-32 |
<0.2% |
- |
50±2% |
4-7 |
|
VA64E |
60/40 |
30-36 |
<0.2% |
< 0.5% |
50±2% |
- |
|
VA64W |
60/40 |
30-36 |
<0.2% |
- |
50±2% |
4-7 |
|
VA64(powder) |
60/40 |
26-34 |
<0.2% |
<5.0% |
>95% |
6-8 |
|
VA55E |
50/50 |
28-36 |
<0.2% |
< 0.5% |
50±2% |
- |
|
VA37E |
30/70 |
28-36 |
<0.2% |
< 0.5% |
50±2% |
- |
|
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