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Phenylbutazone CAS 50-33-9
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Phenylbutazone CAS 50-33-9 is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation


Physical properties 

White or almost white crystalline powder; odorless, slightly bitter, soluble in acetone or chloroform, soluble in ethanol or ether, almost insoluble in water; dissolved in alkali hydroxide solution.


Phenylbutazone antipyretic analgesic effect is less than acetylsalicylic acid, and the toxicity is large, it is generally not for antipyretic analgesic medicine, but its anti-inflammatory effect is strong, can be used for the treatment of rheumatism and rheumatoid arthritis, Acute gouty arthritis, ankylosing spondylitis. In

addition, this product can reduce uric acid from the renal tubular reabsorption, mild urination, can also be used for acute gout patients. Often continuous administration or with other drugs used in conjunction. Can also be used for the treatment of acute schistosomiasis, filariasis acute lymphangitis, tuberculosis, 

malignant tumors caused by fever and so on .



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