Product name: 4‑(Aminomethyl)benzoic acid (P‑Aminomethylbenzoic Acid, PAMBA)
CAS‑No.: 56‑91‑7
EC/EINECS No.: 200‑297‑9
Synonym: Aminomethylbenzoic Acid, PAMBA
Molecular Formula: C8H9NO2
Molecular Weight: 151.17 g/mol
Grade: Pharmaceutical Intermediate / API Grade
Product Description
4‑(Aminomethyl)benzoic Acid (PAMBA) is an antifibrinolytic pharmaceutical intermediate / active pharmaceutical ingredient. It appears as white or off‑white crystalline powder. It is a lysine analogue, inhibiting plasminogen activation to achieve hemostatic effect. It is key raw material for hemostatic pharmaceutical preparations.
Physical‑Chemical Properties
Density 1.22 g/cm³
Boiling point 323.1 ℃ (760 mmHg, predicted)
Flash point 149.2 ℃ (predicted)
Solubility Slightly soluble in cold water; soluble in hot water; practically insoluble in ethanol, ether
Stability Stable under normal conditions; avoid strong oxidants, strong acid & alkali
Typical Quality Specifications
| Item | Specification | Test Method |
|---|---|---|
| Appearance | White to off‑white crystalline powder | Visual inspection |
| Assay (dried basis), % | 98.5 ~ 101.0 | Titration |
| Identification | IR spectrum conforms to reference standard | IR |
| Melting point, ℃ | ≥300 (decomposition) | Capillary melting‑point apparatus |
| Loss on drying, % | ≤ 0.5 | Vacuum drying |
| Residue on ignition, % | ≤ 0.1 | Gravimetric ignition |
| Chloride, % | ≤ 0.02 | Titration |
| Sulfate, % | ≤ 0.02 | Titration |
| Heavy metals (Pb), ppm | ≤10 | AAS |
| Total related substances, % | ≤0.30 | HPLC |
Applications
Pharmaceutical API: Antifibrinolytic hemostatic drug, used for bleeding caused by hyperfibrinolysis, surgical bleeding, gynecological hemorrhage.
Pharmaceutical intermediate: Synthetic building block for other fine‑chemical derivatives.
Packaging & Transportation
HS Code: 2922499990
UN‑Number: Non‑dangerous goods
Package: 25 kg fiber drum with inner PE liner
Storage: Store in cool, dry, dark and well‑ventilated warehouse. Keep tightly sealed, protect from moisture.
Shelf‑life: 36 months under recommended storage conditions.
Hazard Summary
Warning. May cause skin irritation, serious eye irritation, respiratory irritation from dust inhalation. Wear dust‑proof mask, chemical‑resistant gloves and safety goggles during handling. For complete safety guidance please refer to SDS document.
Disclaimer
All information given is based on present laboratory knowledge for reference purpose only, does not constitute product warranty. Users shall verify suitability for own process and comply with local regulatory requirements.
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