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Diphenhydramine Hydrochloride CAS 147-24-0 is white crystalline powder, to eliminateall kinds of allergic symptoms,The central inhibition effect significantly, but not as good as promethazine hydrochloride.
Appearance White crystalline powderMelting range 167.0-172.0℃
Loss on drying 0.5%max
Residue on ignition 0.1%max
Diphenhydramine is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms. Diphenhydramine also has local anesthetic properties, and has been used as such in people allergic to common local anesthetics such as lidocaine.
Diphenhydramine has been found to have a higher efficacy in treatment of allergies than some second-generation antihistamines (such as desloratadine) but a similar efficacy with others (such as cetirizine).
Diphenhydramine is used to treat Parkinson's disease-like extrapyramidal symptoms caused by antipsychotics.
Because of its sedative properties, diphenhydramine is widely used in nonprescription sleep aids for insomnia. The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as acetaminophen (paracetamol). An example of the latter is Tylenol PM. Diphenhydramine can cause minor psychological dependence. Diphenhydramine can cause sedation and has also been used as an anxiolytic.
NauseaDiphenhydramine also has antiemetic properties, which make it useful in treating the nausea that occurs in vertigo and motion sickness.