2-Pyrrolidone 99.9%min (CAS 616-45-5) is a hygroscopic high-boiling polar solvent, widely used as intermediate for PVP and pharma products, and as cosolvent for coatings, inks and polymer processing. TNJ Chemical is the leading manufacturer and exporter in China since 2001. We guarantee high quality, competitive price and thoughtful sales service. If you want to buy or have any inquiry, please contact sales@tnjchem.com
1. Product Information
Product name: 2‑Pyrrolidone
CAS No.: 616-45-5
EINECS No.: 210-483-1Chemical Formula: C₄H₇NO
Molecular Weight: 85.11
Synonyms: 2-Pyrrolidinone, Butyrolactam, α-Pyrrolidone
Appearance: Colorless to pale yellow clear liquid or crystalline solid at low temperature, faint amine-like odor Product
Type : Polar high-boiling solvent, pharmaceutical intermediate, organic synthesis raw material.
2. Physical & Chemical Properties
Density (20 °C) 1.110-1.120 g/cm³
Melting Point 23-25 °C
Boiling Point 245 °C (101.3 kPa)Flash Point (Open Cup) 129 °C
Auto-ignition Temperature 395 °C
Vapor Pressure (20 °C) 0.04 hPa
Solubility Completely miscible with water, alcohols, ethers and most organic solvents; poorly soluble in petroleum ether
Refractive Index n₂₀ᴰ 1.486-1.488
pH (10 % aqueous solution) 9.0-11.0
Stability Hygroscopic. Stable under normal conditions. Incompatible with strong oxidizing agents and strong bases. Combustible.3. Quality Specification (Industrial / Pharma Grade)
| Test Item | Specification (Pharma Grade) |
|---|---|
| Appearance | Colorless clear liquid |
| Identification | IR spectrum matches reference standard |
| Assay (GC) | ≥99.5 % |
| Color (Pt‑Co / Hazen) | ≤15 |
| Moisture (Karl Fischer) | ≤0.10 % |
| Gamma‑Butyrolactone (GBL) | ≤0.05 % |
| Free Amine | ≤0.05 % |
| Refractive Index n₂₀ᴰ | 1.486‑1.488 |
| Density (20 °C) | 1.110‑1.114 g/cm³ |
| pH (10 % aqueous solution) | 9.0‑11.0 |
| Residue on Ignition | ≤0.05 % |
| Heavy Metals | ≤10 ppm |
| Total Organic Impurities | ≤0.30 % |
| Single Individual Impurity | ≤0.10 % |
4. Applications
Organic synthesis: Key starting material for manufacturing N-Vinylpyrrolidone (NVP), PVP and pharmaceutical intermediates such as Piracetam.
Industrial solvent: Cosolvent for coatings, water‑based inks, resin and agrochemical formulations.
Polymer industry: Plasticizer and setting agent for acrylic-styrene floor polish.
Other uses: Aromatic extractant, decolorizing agent for kerosene and fatty acids, raw material for nylon-4 synthesis.5. Packaging, Storage & Transportation
- Packaging: 200 kg steel drum; IBC tank available.
- Storage: Keep container tightly sealed. Store in cool, dry and ventilated warehouse. Prevent moisture absorption. Keep away from heat source and oxidizing substances.
- Transport: Ordinary combustible liquid. Avoid direct sunlight and rain.6. Safety Remarks (Refer to SDS for full details)
- May cause irritation to eyes, skin and respiratory tract. Wear chemical‑resistant gloves and safety goggles during operation.
- In case of contact, rinse with plenty of clean water.
- Fire-extinguishing media: foam, dry powder, carbon dioxide, water spray.
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