1. Basic Product Information
Chemical Name N‑Acetyl‑L‑Cysteine
Synonyms Acetylcysteine, 2‑Acetamido‑3‑mercaptopropionic acid, NAC
CAS Number 616‑91‑1
EC Number 210‑498‑3
Molecular Formula C₅H₉NO₃S
Molecular Weight 163.19 g/molHS‑Code 29309090
2. Chem‑Physical Properties
Appearance White to off‑white crystalline powder
Odor Slight garlic‑like odor
Melting point 106‑108 °C
Specific optical rotation [α]₂₀/D +21.3° ~ +27.0° (10 % in water)
pH (10 g/L aqueous solution) 2.0‑2.8
Solubility in water Freely soluble, ~179 g/L @20℃
Solubility Soluble in ethanol; practically insoluble in ether, chloroform
Hygroscopicity Hygroscopic; sensitive to air & oxidation (‑SH group easy to oxidize)
Flash point 200.4 °C
Vapor pressure (25 °C) Very low
3. Quality Specification (Pharma / Food‑grade)
| Test Item | Unit | Specification | Typical Result | Test Method |
|---|---|---|---|---|
| Appearance | — | White crystalline powder | Complies | Visual |
| Assay (Titration) | % | 98.5‑101.0 | 99.4 | Iodine titration |
| Specific Optical Rotation | ° | +21.3 ~ +27.0 | +23.6 | Polarimeter |
| pH (10 g/L) | — | 2.0‑2.8 | 2.4 | Potentiometry |
| Solution clarity | — | Clear & colourless | Complies | Visual |
| Chloride (Cl⁻) | % | ≤0.04 | 0.015 | EP‑221 |
| Sulphate (SO₄²⁻) | % | ≤0.03 | 0.012 | EP‑221 |
| Ammonium (NH₄⁺) | % | ≤0.02 | 0.008 | Nessler’s reagent |
| Residue on ignition | % | ≤0.20 | 0.08 | Gravimetric |
| Heavy metals (as Pb) | ppm | ≤10 | <5 | AAS |
| Arsenic (As) | ppm | ≤1 | <1 | AAS |
4. Application & Use
Pharmaceutical raw material: mucolytic expectorant agent; antidote for acetaminophen overdose; raw material for injection & oral formulations。
Health‑care / food additive: antioxidant, glutathione precursor, dietary supplement raw material.
Cosmetic raw material: antioxidant, skin‑brightening ingredient, free‑radical scavenger.
Biochemical reagent: culture medium additive, thiol‑reducing agent for lab synthesis.
Important note: Vulnerable to oxidation; avoid long‑term contact with air.
5. Packing
Standard packing: 25 kg fiber drum with inner double PE bag
Small lab package: 1 kg / 5 kg aluminum‑plastic bagKeep inner bag fully sealed.
6. Storage & Transportation
Storage
Store in cool, dry, well‑ventilated warehouse, recommended storage temperature 2‑8 °C, max below 25 °C. Keep container hermetically sealed.
Hygroscopic & oxidation‑sensitive, strictly avoid air, moisture and strong oxidizing agents.
Shelf‑life: 24 months under recommended storage.
Transportation
Non‑dangerous goods for international transport
Proper Shipping Name: N‑Acetyl‑L‑Cysteine
Protect package from rain, high humidity, high temperature during transit. Prevent package breakage.
chemical.tnj
+8618949823763
tnjchem
2881500864