General Product Data
Product Name Climbazole
CAS Number 38083-17-9
EINECS‑EC 253-775-4Synonyms 1-(4-Chlorophenoxy)-3,3-dimethyl‑1‑(imidazol-1-yl)-2-butanone; Ganbaosu
Molecular Formula C15H17ClN2O2
Molecular Weight 292.76 g/mol
Chemical Family Imidazole-derived antifungal cosmetic active ingredient
Available Grade Cosmetic Grade
Regulatory Status REACH registered; Non-CMR, Non-PFAS, Non-nano; Complies with cosmetic regulation limits
Physical & Chemical Characteristics
Physical form White to off-white crystalline powder
Odour Faint characteristic odour
Melting Point 94-98 °CDensity (20 °C) 1.20 g/cm³
Solubility in water Practically insoluble
Solubility Soluble in ethanol, methanol, isopropanol and polar organic solvents
pH scope of stability pH 4-8, stable under acidic and weak‑alkaline cosmetic formulation conditions
Bulk density 420-580 kg/m³
Processing hint Heat-stable; avoid strong oxidizing agents. Dissolve in alcohol prior to adding into aqueous cosmetic systems.
Quality Requirements
| Test Parameter | Cosmetic Grade | Test Method |
|---|---|---|
| Assay (HPLC) | ≥99.0 % | High‑Performance Liquid Chromatography |
| Appearance | White to off‑white crystalline powder | Visual inspection |
| Melting Point | 94‑98 °C | Capillary melting‑point apparatus |
| Loss on Drying | ≤0.50 % | Vacuum gravimetry |
| Sulphated Ash | ≤0.20 % | Gravimetry |
| p‑Chlorophenol impurity | ≤150 ppm | HPLC |
| Heavy Metals (as Pb) | ≤10 ppm | AAS |
Main Functions & Recommended Applications
Anti-dandruff hair-care: Key active ingredient for anti-dandruff shampoo, rinse‑off conditioner, scalp treatment lotion, inhibits Malassezia to reduce dandruff and scalp itch.
Leave-on hair care: Hair tonic, scalp serum for long-term scalp conditioning.
Body-care products: Anti-fungal additive for body wash and soap formulations.
Cosmetic preservative booster: Enhance anti‑microbial performance of creams and lotions.
Important note:
Climbazole is almost insoluble in water; pre-dissolution in ethanol or glycol is required before compounding cosmetic formulations. Do not exceed regulatory maximum permitted dosage in finished cosmetics. End-user shall validate suitability for own formulation and final application. Refer to SDS for full safety guidance.
Logistics & Storage Information
Packaging options: 25 kg fibre-drum with inner PE liner; or as per request.
Lead-time: Samples: 7-15 working days against deposit.
Storage condition: Keep container tightly closed. Store in cool, dry, well-ventilated warehouse, keep away from heat source, alkali and oxidizing agents. Protect from direct sunlight.
Shelf-life: 24 months under original sealed storage.



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