General overview of Chlorhexidine Gluconate 20% aqueous solution CAS 18472-51-0
Chlorhexidine Gluconate CAS 18472-51-0 is a biguanide chlorobenzene with a wide range of antimicrobial activity (Aly and Maibach, 1983; Goldblum et al. 1983; Sebben, 1983). At pH 5.0-8.0, it is most effective against Gram-positive (10mcg/ml) and Gram-negative (50mcg/ml) bacteria. It is colorless or light yellow almost transparent and slightly viscous liquid; odorless or almost odorless. This product is miscible with water and dissolves in ethanol or acetone. Relative density: 1.060~1.070g/ml (25℃).
| Item | Specification | Test Method |
|---|---|---|
| Appearance | Almost colourless to pale‑yellow slightly viscous clear liquid | Visual inspection |
| Assay (Chlorhexidine Digluconate), wt% | 19.0 ~ 21.0 | Titration |
| pH (5 % aqueous solution) | 5.5 ~ 7.0 | pH‑meter |
| Density (20℃), g/cm³ | 1.060 ~ 1.070 | Hydrometer |
| Related Substances | Complies with standard specification | HPLC |
| p‑Chloroaniline, % | ≤ 0.05 | HPLC |
Application
Chlorhexidine Gluconate is a cationic biguanide‑type broad‑spectrum bactericidal antiseptic agent. It shows strong killing effect for gram‑positive bacteria, gram‑negative bacteria, partial fungi and enveloped viruses, and retains long‑lasting residual antibacterial activity after application.
Medical & Healthcare
Pre‑operative skin disinfection, surgical hand scrub for hospital use.
Wound and mucosal antisepsis, skin preparation before injection / catheter operation.
Raw material for disinfectant wipes, antiseptic lotions for infection‑control purpose.
Dental / Oral‑care Industry
Key functional ingredient for mouthwash. Inhibits dental plaque formation, relieves gingivitis, gum inflammation and postoperative oral infection after dental surgery.
Cosmetic & Personal‑care
Preservative and bacteriostatic raw material for skincare, personal hygiene formulations.
Veterinary field
Skin and wound disinfection for pets and livestock; sanitizing agent for veterinary surgical sites and equipment.
Industrial surface disinfection
Sanitizer for equipment surfaces in pharmaceutical and food‑processing workshops.
Packing
25kg/drum or 200kg/HEDP drum or as per customers' request




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