Product name: 3-Pyridinecarboxaldehyde
CAS No.: 500-22-1
Synonyms: Nicotinaldehyde, 3-Formylpyridine, Pyridine-3-carbaldehyde
Molecular Formula: C6H5NO
Molecular Weight: 107.11
EC No.: 207-900-4SMILES: O=Cc1cccnc1
Brief Introduction
3-Pyridinecarboxaldehyde (Nicotinaldehyde) is an important pyridine-based fine chemical intermediate. It appears as pale yellow to light brown transparent oily liquid at ambient temperature. This molecule contains pyridine ring and reactive aldehyde functional group, which readily participates in condensation, reduction, cyclization and Schiff base formation reactions.
Typical Physical & Chemical Properties
Appearance: Pale yellow to light brown clear liquid
Melting Point: ~7–8 ℃
Boiling Point: 222–225 ℃ (760 mmHg)
Density (20 ℃): 1.140 ~ 1.148 g/mL
Refractive Index n₂₀ᴰ: 1.548 ~ 1.552
Flash Point: 60 ℃
Solubility: Miscible with water, ethanol, methanol, chloroform and common organic solventsStability: Stable under normal storage; sensitive to prolonged strong light; avoid strong oxidants and strong alkali.
Quality specification
| Item | Specification | Test Method |
|---|---|---|
| Appearance | Pale yellow to light brown clear liquid | Visual Inspection |
| Assay (GC) | ≥97.0 % | Gas Chromatography |
| Water Content (KF) | ≤0.20 % | Karl Fischer Titration |
| Color (Pt-Co) | ≤250 Hazen | Platinum-Cobalt Method |
| Evaporation Residue | ≤0.10 % | Gravimetry |
Main Applications
- Key intermediate for pharmaceutical synthesis: used to manufacture cardiovascular drugs, anti-inflammatory agents, antibacterial and antitumor pyridine-series APIs.
- Raw material for agrochemicals: pesticide, fungicide and plant growth regulator intermediates.
- Dye & photosensitive material intermediate for preparing pyridine-based colorants.
- Ligand raw material for coordination chemistry and catalyst synthesis.
- Analytical reagent and building block for organic fine synthesis.
Packing, Handling & Storage
Packing: 25 kg / 200 L HDPE plastic drum
Store in tightly sealed containers in cool, dry, dark and ventilated warehouse.Shield from direct sunlight and high temperature.
Separate from strong oxidizing agents, strong bases.
Avoid vapor inhalation and direct skin & eye contact; wear chemical resistant gloves and safety goggles.
Shelf life: 12 months under recommended storage.



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