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500-22-1
CAS 500-22-1 3-Pyridinecarboxaldehyde
  • CAS:

    500-22-1
  • Alias:

    Nicotinaldehyde
  • EINECS:

    207-900-4
  • Molecular Formula:

    C6H5NO
  • Quality Standard:

    98%min
  • Packing:

    25kg/drum or as per request
  • Factory Site:

    Anhui, China
  • Mininmum Order:

    1kg
  • Price inquiry:

    sales@tnjchem.com
  • Manufacturer:

    TNJ Chemical

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  • Product Details

Product name: 3-Pyridinecarboxaldehyde

CAS No.: 500-22-1

Synonyms: Nicotinaldehyde, 3-Formylpyridine, Pyridine-3-carbaldehyde

Molecular Formula: C6H5NO

Molecular Weight: 107.11

EC No.: 207-900-4

SMILES: O=Cc1cccnc1

 

Brief Introduction

3-Pyridinecarboxaldehyde (Nicotinaldehyde) is an important pyridine-based fine chemical intermediate. It appears as pale yellow to light brown transparent oily liquid at ambient temperature. This molecule contains pyridine ring and reactive aldehyde functional group, which readily participates in condensation, reduction, cyclization and Schiff base formation reactions.

 

Typical Physical & Chemical Properties

Appearance: Pale yellow to light brown clear liquid

Melting Point: ~7–8 ℃

Boiling Point: 222–225 ℃ (760 mmHg)

Density (20 ℃): 1.140 ~ 1.148 g/mL

Refractive Index n₂₀ᴰ: 1.548 ~ 1.552

Flash Point: 60 ℃

Solubility: Miscible with water, ethanol, methanol, chloroform and common organic solvents

Stability: Stable under normal storage; sensitive to prolonged strong light; avoid strong oxidants and strong alkali.

 

Quality specification

Item Specification Test Method
Appearance Pale yellow to light brown clear liquid Visual Inspection
Assay (GC) ≥97.0 % Gas Chromatography
Water Content (KF) ≤0.20 % Karl Fischer Titration
Color (Pt-Co) ≤250 Hazen Platinum-Cobalt Method
Evaporation Residue ≤0.10 % Gravimetry

 

Main Applications

- Key intermediate for pharmaceutical synthesis: used to manufacture cardiovascular drugs, anti-inflammatory agents, antibacterial and antitumor pyridine-series APIs.

- Raw material for agrochemicals: pesticide, fungicide and plant growth regulator intermediates.

- Dye & photosensitive material intermediate for preparing pyridine-based colorants.

- Ligand raw material for coordination chemistry and catalyst synthesis.

- Analytical reagent and building block for organic fine synthesis.

 

Packing, Handling & Storage

Packing: 25 kg / 200 L HDPE plastic drum

Store in tightly sealed containers in cool, dry, dark and ventilated warehouse.

Shield from direct sunlight and high temperature.

Separate from strong oxidizing agents, strong bases.

Avoid vapor inhalation and direct skin & eye contact; wear chemical resistant gloves and safety goggles.

Shelf life: 12 months under recommended storage.

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