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Artemether
  • CAS No.:

    71963-77-4
  • Molecular Formula:

    71963-77-4
  • Quality Standard:

    Enterprise standard
  • Packing:

    25kg/fiber drum
  • Mininmum Order:

    25kg

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  • Product Details
Artemether CAS 71963-77-4 is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria. Chemically, it is a semi-synthetic derivative of artemisinin. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.Its is available in combination with lumefantrine. This combination is available as generic medication.

 

Properties

White Crystal or crystalline powder. Very soluble in actone and chloroform, slightly soluble in ethanol, not soluble in water
-Density:           1.18g/cm3
-Boiling Point:   358℃ at 760mmHg
-Melting point:   86~89℃
-Flashing Point: 141℃
-Refractive Index:  1.518

Specification

Appearance                      White crystal or crystalline powder
Specific rotation               +168.0o~+173.0o
Chloride                            ≤0.01%
Related substances          Simple impurity ≤1.0%
Total other impurity          ≤0.5%
Loss on Drying                  ≤0.5%
Residue on ignition           ≤0.1%
Methanol                           ≤0.5%
Chloroform                        ≤0.3%
Assay                                98.0 ~ 102.0%

Application

Artemether is effective against the blood schizonts of both malarial parasites P. falciparum and P. vivax. It, however, may not be as good as artesunate for severe malaria.

It is available by itself, but usually given in combination with lumefantrine in treatments of malaria. World Health Organization guidelines for the treatment of uncomplicated falciparum malaria recommend the use of this artemisinin-based combination therapy. Zambia was the first African country to adopt artemether/lumefantrine (commonly called Coartem) as first-line therapy in national malaria treatment guidelines in 2002. Clinical records show that by 2008, the rates of in-patient malaria cases and deaths decreased by 61% and 66%, respectively, compared with the 2001-2002 reference period. In South Africa, also, the number of malaria-related outpatient cases and hospital admissions of each fell by 99% from 2001 to 2003, and malaria-related deaths decreased by 97% over the same period.


Packing

1kg/aluminum foil bag, 25kgs/fiber drum

Storage

Store in a cool, ventilated place.


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